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Acoustic Membrane MicroParticle (AMMP) technology is the unique integration of the microelectromechanical systems (MEMS) sensors,biological capture strategies, and magnetic microparticles creating a highly-sensitive, non-optical protein detection technique that is highly robust and versatile.
AMMP non-optical detection technology determines protein concentration by measuring the mass of the analyte amplified by the mass of the bound magnetic microparticles. The microparticles capture the analyte, reduce sample matrix interference, provide rapid transport of captured analytes to the sensor surface, and provide the bulk of the sensor loading, thus resulting in a measurable signal that is tracked by observing the sensor response.
The exquisite sensitivity of the resonating membrane, the functionalization of the surface of the membrane with a capture agent that specifically binds the analyte of interest, and the signal enhancement through the use of magnetic microparticles combine to make the sensor highly specific, sensitive and robust in a complex matrix.